Principle InvestigatorJim Jinn-Chyuan Sheu, Associate Professor
Research Area
Cancer Genomics/Genetics, New Drug Development
Location
11F Fu-Jian Bldg, Human Genetic Center
Telephone
(O) 777-2037, (L)777-2005, 777-2002,  777-2043
E-mail
jimsheu@mail.cmu.edu.tw

Position | Educational History | Working Experience | Specialty | AWARDS/HONORS |

 Summary | Lab Members | Publication |

◎【Position

 Associate Professor   Graduate Institute of Chinese Medical Science/School of Chinese Medicine,
                                  China Medical University

 Research Fellow       Human Genetic Center/China Medical University Hospital

 Associate Professor   Department of Health and Nutrition Biotechnology/Asia University
.........................................................................................................................................................................................

◎【
Educational History

 B.S.    Department of Biology (Life Science)/Fu-Jen University (1990-1994)

 MS     Department of Life Science/National Tsing-Hua University (1995-1996)

 Ph.D.   Department of Life Science/National Tsing-Hua University (1996-2002)

 Post-Doc  Department of Oncology & Pathology/Johns Hopkins Medical Institute (2004-2006)

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◎【Working Experience

  Research Fellow       BioMedicine Division/Development Center for Biotechnology (2003-2004)

  Assistant Professor   General Educational Center, Chang-Gung University, (2003-2004)

  Visiting Researcher   Institute of BioMedical Science, Academia Sinica (2003-2004)

  Visiting Professor     Department of Oncology & Pathology/Johns Hopkins Medical Institute
                                 (2006-2007)

 Assistant Professor   Graduate Institute of Chinese Medical Science/School of Chinese Medicine,
                                China Medical University (2006-2009)

 Assistant Professor   Department of Health and Nutrition Biotechnology/Asia University (2007-2009)

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◎【Specialty

  Cancer Genomics/Genetics, Modern Chinese Medicine, New Drug Development, Biotechnology

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◎【
AWARDS/HONORS

2005             Basic Science 1st Place Winners of Fellow Research Day

                     The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

2003             Government-financed student sponsored by Ministry of Education/Taiwan

2008              Best innovation in basic research and teaching
      Summer student program sponsored by National Science Council

2008-2011    Outstanding Research Award sponsored by China Medical University

2009              Medical Young Investigator Award sponsored by Prof. Chen-Yuan Lee  
      Foundation

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◎【
Summary

It has been known that a person's genetic background interacts with the environment and stochastic factors in determining the susceptibility to certain diseases, such as neoplastic, infectious, or autoimmune diseases. Hence, abnormalities of genetic content and gene expression levels have been related to certain types of diseases. My research interest focuses on discovery of disease-related target genes and functional analyses to verify their roles in pathogenesis. Especially, diseases frequently found in Asian population will be my first priority to explore. With the development of genome-wide technologies, such as digital karyotyping map, SNP arrays, SAGE libraries, micro-RNA profiling, epigenetic analyses, and protein structure/function predictions, we can identify disease-driving genes (or biomarkers) that involve in the pathogenesis pathway in a robust format from DNA to the protein levels. These novel technologies speed up the process of new target discovery and new drug development.

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◎【
Lab Members

  P.I.: Dr. Jim Jinn-Chyuan Sheu

  Members: Chih-Mei Chen, Carmen Chan, Ivy I-Wen Chiu, Yu-Wen Chiu, Ya-Ro Ding,
                  Ya-Yun Huang, Ya-Ing Lin, Suh-Han Yang, and Pei-Wen Tsai

  Alumni: Iris Chun-Yi Lin, Peter Yih-Shyuan Wu, Hung-Chieh Tsai, Tsai-Ling Shih, Tsong-Yu Lee,
              Tseng-Yu Yang, Li-Yu Wang

.........................................................................................................................................................................................


◎【
Publication

A.     Journal articles

   Cancer related publications

 

1. Sheu JC, Hsu CP, Yang CC, Yang SD. (1998) Acute inductive effects on oncogenic proline-directed protein kinase (PDPK) FA/GSK-3a in NIH 3T3 cells by ethanol and cadmium. Proc. Natl. Sci. Counc. Repub. China B. 22:68-75.

2. Yang CC, Hsu CP, Sheu JC, Mai XY, Yang SD. (1998) Differential tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase (PDPK) FA/GSK-3a in well and poorly differentiated human prostate carcinoma cells. J. Protein Chem. 17:329-35.

3. Huang J, Sheu JJ, Wu SC, Chang TW. (2002) Down regulation of B cells by immunization with a fusion protein of a self CD20 peptide and a foreign IgG.Fc fragment. Immunol. Lett. 81:49-58.

4. Sheu JJC, Huang J, Chang TW. (2002) Inducing specific reactivity against B cells in mice by immunizing with an Fc fusion protein containing self-Igβ. Cancer Immunol. Immunother. 51:145-151.

5. Sheu JJC, Huang J, Cheng T, Lim C, Chang TW. (2003) Comparative effects of human Igαand Igβ in inducing auto-/cross-reactive antibodies against B cells in mice. J. Immunol. 170:1158-66.

6. Shih IeM, Sheu JJ, Santillan A, Yu CH, Yen MJ, Hwang T, Nakayama K, Bristow RE, Vang R, Parmigiani G, Kurman RJ, Trope CG, Davidson B, Wang TL. (2005) Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proc. Natl. Acad. Sci. USA. 102:14004-9. CXJXA=3X9.598X3=86.382.

7. Mao TL, Hsu CY, Yen MJ, Gilks B, Sheu JJ, Gabrielson E, Vang R, Cope L, Kurman RJ, Wang TL, Shih IeM. (2006) Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma. Hum Pathol. 37:1169-75. CXJXA=3X4X0.5=6.

8. Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Salani R, Kurman RJ, Morin P, Santillan A, Bristow RE, Shih IeM, Wang TL. (2006) A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Proc. Natl. Acad. Sci. USA. 103:18739-44. CXJXA=3X9.598X0.5=14.397.

9. Sheu JJ-C, Shih I-M. (2007) Clinical and biological significance of HLA-G expression in ovarian cancer. Semin Cancer Biol. 17:436-43. CXJXA=2X7.510X5=75.1.

10. Wan L, Lin CW, Lin YJ, Sheu JJ, Chen BH, Liao CC, Tsai Y, Lin WY, Lai CH, Tsai FJ. (2008) Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2 : STAT6 heterodimer. J Cell Mol Med. 12; 876-88. CXJXA=3X6.801X0.5=10.202.

11. Sheu JJ, Choi JH, Yýldýz I, Tsai FJ, Shaul Y, Wang TL, Shih IM. (2008) Modulating the tumor-promoting functions of Rsf-1 by dimer formation with hSNF2H. Cancer Res. 68; 4050-7. CXJXA=3X7.672X5=115.08.

12. Lee CH, Fang CY, Sheu JJ, Chang Y, Takada K, Chen JY (2008) Amplicons on chromosome 3 contain oncogenes induced by recurrent TPA / SB exposure and Epstein-Barr virus reactivation in a nasopharyngeal carcinoma cell line. Cancer Genetics and Cytogenetics. 185: 1-10. CXJXA=3X2X1=6.

13. Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ. (2009) Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun. 378: 683-8. CXJXA=3X4X0.5=6.

14. Choi JH, Sheu JJ, Guan B, Jinawath N, Markowski P, Wang TL, Shih IM. (2009) Functional analysis of 11q13.5 amplicon identifies Rsf-1 (HBXAP) as a gene involved in paclitaxel resistance in ovarian cancer. Cancer Res. 69:1407-15. CXJXA=3X7.672X3=69.048.

15. Sheu JJ, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Jinawath N, Tsai MH, Chang NW, Lin CF, Lin CC, Hsieh LJ, Wang TL, Shih IeM, Tsai FJ. (2009) Functional genomic analysis identified EGFR activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res. 69:2568-76. CXJXA=3X7.672X5=115.08.

16. Sheu JJ, Lee CH, Ko JY, Tsao G, Wu CC, Fang CY, Tsai FJ, Hua CH, Chen CL, Chen JY. (2009) Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 are genomic markers for prognosis of advanced nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 18:2709-16. (JCR2008: IF = 4.770; Rank = 8/105)

 

   Other publications

1. Lin YJ, Wan L, Sheu JJC, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH Tsai FJ. (2008) A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients. Lupus. 17: 124-7. CXJXA=3X3X1=9.

2. Lin YJ, Wan L, Sheu JJ, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin WY, Liu HP, Lin TH, Huang YM, Tsai FJ (2008) G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clin Immunol. 129:36-9. CXJXA=3X4X1=12.

3. Chang HL, Tang CH, Hsu YM, Wan L, Chang YF, Lin CT, Tseng YR, Lin YJ, Sheu JJ, Lin CW, Chang YC, Ho MW, Lin CD, Ho CM, Lai CH. (2009) Nosocomial Outbreak of Infection With Multidrug-Resistant Acinetobacter baumannii in a Medical Center in Taiwan. Infect Control Hosp Epidemiol. 30: 34-8. CXJXA=3X5X0.5=7.5.

4. Wan L, Lin YJ, Sheu JJ, Huang CM, Tsai Y, Tsai CH, Wong W, Tsai FJ. (2009) Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus. Int. J. Immunogenetics. 36:33-7. CXJXA=3X1X5=15. (Co-first author)

5. Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, Tsai FJ. (2009) HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arth & Rheum. 60:604-10. CXJXA=3X7.677X0.5=11.515.

6. Wan L, Kung YJ, Lin YJ, Liao CC, Sheu JJ, Tsai Y, Lai HC, Peng CY, Tsai FJ. (2009) Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-alpha. Biochem Biophys Res Commun. 379:855-60. CXJXA=3X4X0.5=6.

7. Chen SY, Wan L, Huang YC, Sheu JJ, Lan YC, Lai CH, Lin CW, Chang JS, Tsai Y, Liu SP, Lin YJ, Tsai FJ. (2009) Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease. J Clin Lab Anal. 23:71-6.

8. Lin YJ, Chen RH, Wan L, Sheu JC, Huang CM, Lin CW, Chen SY, Lai CH, Lan YC, Hsueh KC, Tsai CH, Lin TH, Huang YM, Chao K, Chen DY, Tsai FJ. (2009) Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus. 18:974-9.

9. Liu HP, Lin YJ, Lin WY, Wan L, Sheu JJ, Lin HJ, Tsai Y, Tsai CH, Tsai FJ (2009) A novel genetic variant of BMP2K contributes to high myopia. J Clin Lab Anal. 23:362-7.

10. Lin HJ, Kung YJ, Lin YJ, Sheu JJ, Chen BH, Lan YC, Lai CH, Shu YA, Wan L, Tsai FJ. (2010) Association of the Lumican gene functional 3' UTR polymorphism with high myopia. Invest Ophthalmol Vis Sci. 51:96-102.

 

B.  Conference report

1. Sheu JJC, Chang TW. (2000)

Induction of specific autoantibodies against CD79a in mice by immunizing with human CD79a fused with IgG1.Fc.

FASEB J. 14(6):A1123

2. Leslie YY, Sheu JJC, Chang TW. (2000)

Regulation of B cell activity by inducing specific autoimmune response against CD79b.

FASEB J. 14(6):A1123.

3. Sheu JJ, Yu T, Huang ML, Tsai WL. (2002)

Suppressing tumor progression and inducing cell differentiation on prostate cancer cells by human psychosomatic power.

Experimental Biology 2002. 257.6:31.

4. Sheu JJ, Chen MY, Chang TW. (2002)

Preparation of recombinant human anti-enterovirus 71 neutralizing antibodies for clinical applications.

Experimental Biology 2002. 240.9:87.

5. Sheu JJ, Tsai CC, Hsu CL, Chang TW. (2004)

Preparation of epitope-specific monoclonal antibodies to neutralize SARS-CoV

Experimental Biology 2004. 283:7:21.

6. Sheu JJ, Santillan A, Yu CH, Yen MJ, Hwang T, Nakayama K, Bristow RE, Vang R, Parmigiani G, Kurman RJ, Trope CG, Davidson B, Shih I, Wang TL. (2005)

Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.

Johns Hopkins Fellow’s Day 2005

7. Chiu YW, Lai MT, Li ZY, Wan L, Tsai FJ, Sheu JJC*. (2007)

Oncogenic activity of Rsf-1/HBXAP depends on p53 mutation status

The 1st International Cancer Symposium 2007.

8. Chan C, Shih TL, Tsai FJ, Wan L, Lin YJ, Wang TL, Shih IM, Sheu JJC*. (2007)

Down regulation of chromatin remodeling activity triggers cell death in RSF-1/HBXAP amplified cancer cells.

The 1st International Cancer Symposium 2007.

9. Chiu IW, Chiou YW, Wan L, Lin YJ, Lai CH, Chen SY, Huang CM, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)

Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus.

2008 Taiwan Human Genetic Society Autumn Symposium: page 40. (Oral presentation)

10. Chan C, HsiaoYT, Wan L, Lin YJ, Lai CH, Chen SY, Huang CM, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)

Association analysis of polymorphisms in lumican and systemic lupus erythematosus in Han Taiwan Chinese population.

2008 Taiwan Human Genetic Society Autumn Symposium: page 49. (Oral presentation)

11. Wu YS, Chen CM, Wan L, Lin YJ, Lai CH, Huang CM, Tsai YH, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)

Association between polymorphisms in the DNA repair gene XRCC1 and systemic lupus erythematosus in Han Taiwan Chinese population.

2008 Taiwan Human Genetic Society Autumn Symposium: page 57. (Oral presentation)

12. Sheu JJ (2008.12.06-2008.12.07)

Genome analysis of oral cancer

2008 Asia-Pacific Congress on Oral Cavity Cancer in conjunction with 12th Annual Meeting of Taiwan Cooperative Oncology Group: page 7 (Oral presentation)

13. Chiu IW, Chen CM, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Tsai MH, Tsai FJ, Wang TL, Shih IM, Sheu JJC (2009.4.18-2009.4.22)

Functional genomic analysis identified EGFR activation as the most common genetic event in oral squamous cell carcinoma

2009 100th Annual Meeting of the American Association for Cancer Research

Proceedings of the American Association for Cancer Research (2009) 50: 626.

14. Sheu JJC, Chan C, Chen CM, Hisao E, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Tsai MH, Tsai FJ (2009.4.18-2009.4.22)

Activation of oncogenes at 3q and 8q amplicons by somatic mutations in oral squamous cell carcinoma

2009 100th Annual Meeting of the American Association for Cancer Research

Proceedings of the American Association for Cancer Research (2009) 50: 339.

 

C.  Patent

1. Chang TW, Sheu JJC, Huang JSW, Wu SCS, Chen LYY.

Composition and methods for induction of active autoimmunity.

U.S. Patent Application: 20020102232.

2. Chang TW, Sheu JJC, Lo LH Chen NY, Lin YS.

Recombinant human neutralizing antibodies against enterovirus 71.

(filed in the US, Taiwan and China)

U.S. Patent Number: 7,482,006 issued on Jan 27, 2009.

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