Principle InvestigatorShih-Yin Chen, Ph.D.
Research Area

Location
11F Fu-Jian Bldg, Human Genetic Center
Telephone
+886- 4-22052121 ext 2033
E-mail
chenshihy@mail.cmu.edu.tw

Position | Educational History | Working and Research Experience | Associationist |
 Professional Specialty | Honors and Awards | Interests | Fellows | Publication |
◎【Position

 Assistant Professor   Graduate Institute of Chinese Medical Science/China Medical University

 

.........................................................................................................................................................................................

◎【
Educational History

 Ph.D.   Division of Preventive Medicine, Institute of Public Health, National Yang-Ming University,
             Taichung, Taiwan. (1997.09-2005.09)
 

 MS     Institute of Toxicology, Chung Shan Medical University, Taichung, Taiwan. (1997.09-1999.07)

 B.S.    Department of Nutrition, China Medical University, Taichung, Taiwan. (1992.09-1996.07)

.........................................................................................................................................................................................

◎【
Working and Research Experience

  2009.02-present       Assistant Professor, Graduate Institute of Chinese Medical Science,
                                  China Medical University, Taiwan.

  2008-present            Assistant Research Fellow, Genetic Center, Department of Medical Research,
    China Medical University Hospital.

  2005.10-2008.04     Postdoctoral Fellow,  Section on Cellular Differentiation Heritable Disorders
    Branch, NICHD, NIH, U.S.A.

  1998.09-2005.07     Ph.D. Candidate, Institute of Public Health, National Yang Ming University,
    Taiwan.

  1997.09-1999.07     Institute of Toxicology, Chung Shan Medical University. Taichung, Taiwan,
    Taiwan.

.........................................................................................................................................................................................

◎【Associationist

1. Society of Preventive Medicine in Taiwan (SPMT)

2 The Chinese Society of Cell and Molecular Biology(CSCMB)

3. The Chinese Society of Toxicology(CST)

.........................................................................................................................................................................................

◎【Professional Specialty

   Preventive Medicine, Public Health, Cell and Gene Toxicology, Tumor and Molecular Biology,
  
Genetics and Metabolomics

.........................................................................................................................................................................................

◎【Honors and Awards

  1. Education Award, from the Ministry of Education, Taiwan, 1999~2004.

  2. Research award, excellent publication by Ph.D. candidate, from National Yang Ming University, 2004. (12 number of person per year)

  3. Research award, excellent publication by Ph.D. candidate, from Cancer Control and Prevention Division, Bureau of Health Promotion, Department of Health, The Executive Yuan, Taiwan, Republic of China, 2004. (3 number of person per year)

.........................................................................................................................................................................................

◎【Interests

     The major on-going projects include:

  1.  A Study of the Interaction between Tumor Susceptibility Gene GNMT and Environmental Carcinogens Polycyclic Aromatic Hydrocarbons in Lung Cancer.

  2. A study of Eyes Dysfunction of the mice with Diabetes Mellitus using the type I DM animal model induced by STZ.

  3. Characterization of the biomarker in membranous glomerulopathy disease: using the cohort in Taiwan.

  4. Molecular Epidemiology study in the cohort of Kawasaki disease in Taiwan.

.........................................................................................................................................................................................

◎【Fellows

     Master Assistant Research Fellows:

              Chia-Jung Chan (Melody),

              Xuan-Ming Chuang (IKE)

.........................................................................................................................................................................................


◎【
Publication

A.     Journal articles

 

 1.  Chen, S.Y., Wan, L., Huang, Y.C., Sheu, J.J.C., Lan, Y.C., Lai , C.H., Lin , C.W., Chang, J.S., Tsai, Y., Liu, S.P., Lin, Y.J., Tsai, F.J. Interleukin-18 gene 105A/C genetic polymorphism contributes to the susceptibility of Kawasaki disease. J Clin Lab Anal. 23: 71-76, 2009. (MEDICAL LABORATORY TECHNOLOGY: 20/26; IF: 0.955)

 2.  Yen,  C.H., Hung, J.H., Ueng, Y.F., Liu, S.P., Chen, S.Y., Chou, T.Y., Tsai, T.F., Darbha, R., Ji, X., Hsieh, L.L., and Chen Y.M.A. Glycine N-Methyltransferase Affects the Metabolism of Aflatoxin B1 and Blocks its Carcinogenic Effect. Toxicol Appl Phamacol. 235(3):296-304, 2009. (TOXICOLOGY: 6/73; IF: 3.846)

 3.  Pan, C.J., Chen, S.Y., Lee, S., Chou, J.Y. Structure-function study of the glucose-6-phosphate transporter, an eukaryotic antiporter deficient in glycogen storage disease type Ib. Mol. Genet. Metab. 96(1):32-7, 2009. (MEDICINE, RESEARCH & EXPERIMENTAL: 29/81; IF: 2.55)

 4.  Chen, S.Y., Pan, C.J., Lee, S., Peng, W., Chou, J.Y. Functional analysis of mutations in the glucose-6-phosphate transporter that cause glycogen storage disease type Ib. Mol. Genet. Metab. 95(4):220-3, 2008. (MEDICINE, RESEARCH & EXPERIMENTAL: 29/81; IF: 2.55)

 5. Chen, S.Y., Pan, C.J., Nandigama, K., Mansfield, B.C., Ambudkar, S., Chou, J.Y.  The Glucose-6-Phosphate Transporter is a Phosphate-Linked Antiporter Deficient in Glycogen Storage Disease Type Ib and Ic. FASEB J. 22(7):2206-13, 2008. (BIOLOGY: 3/70; IF: 6.791).

 6. Lee, C.M., Chen, S.Y., Lee, Y.C.G., Huang, C.Y.F. & Chen, Y.M.A. Benzo[a]pyrene and Glycine N-methyltransferase Interactions: Gene Expression Profiles of the Liver Detoxification Pathway. Toxicol Appl Phamacol. 214(2):126-35, 2006. (TOXICOLOGY: 6/73; IF: 3.846)

 7. Chen, S.Y., Lin, J.R.V, Ramalakshmi Darbha, Liu, T.Y. and Chen Y.M.A. Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. Cancer Res. 64(10): 3617-23, 2004. (ONCOLOGY: 10/127; IF: 7.656)

B.  Conference report

 1.  Chen, S.Y., Chia-Jung Chan, C.J., Wan, L., Lin, Y.J., Sheu, J.J.C., Lan, Y.C., Huang, Y.C., Liu, S.P., Chen, Y.M.A., Tsai, F.J. A Study of the Interaction between Tumor Susceptibility Gene GNMT and Environmental Carcinogens Polycyclic Aromatic Hydrocarbons. The 24th Joint Annual Conference of Biomedical Science, Mar. 21-22, 2009 (Oral)

 

.........................................................................................................................................................................................
HOME