Principle InvestigatorChun-Fa Huang
Research Area
Diabetes Mellitus, New Drug Development of the Potential Chinese 
                           Herb Medicine in Anti-diabetes or Regulate Glucose Metabolism
Location
12F Li-Fu Bldg, Core Laboratory of Collage of Chinese Medicine
Telephone
(O) 886-4-22053366 ext:3323
E-mail
cfhuang@mail.cmu.edu.tw
 

Position | Educational History | Working Experience | Specialty | Research Goal |

 Research Plan | Lab Members | Publication |

◎【Position

 Assistant Professor   Graduate Institute of Chinese Medical Science/China Medical University

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◎【
Educational History

  MS     Institute of Toxicology, Collage of Medicine, National Taiwan University (2000.8-2001.9)

  Ph.D.    Institute of Toxicology, Collage of Medicine, National Taiwan University (2001.9-2007.10)
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◎【Working Experience

  Post-Doc  Institute of Toxicology, Collage of Medicine, National Taiwan University (2007.11-
                   2008.7)
 

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◎【Specialty

  Diabetes Mellitus, New Drug Development of the Potential Chinese Herb Medicine in Anti-diabetes
  or Regulate Glucose Metabolism, Toxicology of Chinese Herb Medicine

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◎【
Research Goal

  1. Evaluation of the potential Chinese herb medicine in anti-diabetes or regulate glucose metabolism, and involvement of pharmacological mechanisms

  2.  Evaluation of toxicological effects in Chinese Herb Medicine

  3.  Studies on molecular mechanism of environmental pollutants-induced diabetes

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◎【
Research Plan

Studies on the regulatory effects and its possible mechanisms of a Chinese Traditional Herb  Medicine--Semen Benincasae Extract for improvement of insulin secretion and blood glucose (CMU97-211, 2008/8-2009/7)

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◎【
Lab Members

  P.I.: Chun-Fa Huang

  Members: Tien-Hui Lu, Jyun-Yuan Cai, Tsai-Shan Yang, Jinn-Yu Chen
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◎【
Publication

A.     Journal articles

  1. Rong Sen Yang, Huei Ping Tzeng, Feng Ming Ho, Chia Chi Chuang, Bo Lin Chen, Chun-Fa Huang, Ya-Wen Chen, Ruei Ming Chen, Shing Hwa Liu*.  Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Acta Biomater. 2009 (In press)

  2. Chun-Fa Huang, Chuan-Jen Hsu, Shing-Hwa Liu, Shoei-Yn Lin-Shiau. Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+/K+-ATPase involved. Toxicology Letters 2008 Feb 15; 176(3): 188-197. (SCI)

  3. Chun-Fa Huang, Chuan-Jen Hsu, Shing-Hwa Liu, Shoei-Yn Lin-Shiau. Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na+/K+-ATPase activities. NeuroToxicology 2008 May;29(3):386-96:386-396. (SCI)

  4. Chun-Fa Huang, Shing-Hwa Liu, Shoei-Yn Lin-Shiau. Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice. Toxicology and Applied Pharmacology 2007 Oct 15; 224(2)::192-201.

  5. Cheng-Chieh Yen, Fung-Jou Lu, Chun-Fa Huang, Wen-Kang Chen, Shing-Hwa Liu, Shoei-Yn Lin-Shiau. The Diabetogenic Effects of the Combination of Humic acid and Arsenic: In Vitro and In Vivo Studies. Toxicology Letters 2007 Aug; 172(3)::91-105.

  6. Cheng-Chieh Yen, Chun-Fa Huang, Lee WJ, Hsu MJ, Shing-Hwa Liu, Shoei-Yn Lin-Shiau. Studies on mercurial sulfide, a component of cinnabar, a Chinese herbal medicine, on celluar functions in mouse lung and fibroblasts. Toxicological and Environmental Chemistry. (2007) 90:181-201. (EI)

  7. Ya-Wen Chen, Chun-Fa Huang (Equal first author), Keh-Sung Tsai, Rong-Sen Yang, Cheng-Chieh Yen, Ching-Ya Yang, Shoei-Yn Lin-Shiau, Shing-Hwa Liu. The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury-Induced Mouse Pancreatic β-Cell Dysfunction In Vitro and In Vivo. Diabetes 2006 Jun 55(6): 1614-1624.

  8.  Ya-Wen Chen, Chun-Fa Huang (Equal first author), Keh-Sung Tsai, Rong-Sen Yang, Cheng-Chieh Yen, Ching-Ya Yang, Shoei-Yn Lin-Shiau, Shing-Hwa Liu. Methylmercury induces pancreatic beta-cell apoptosis and dysfunction. Chem Res Toxicol 2006 Aug; 19(8): 1080-1085.

 

B.  Conference report

1.   C.F. Huang, H.S. Liu and S.Y. Lin-Shiau (2002). Low Dose Mercury Sulfide Suppressed The Stimulatory Effects Of Methyl-amphetamine On Locomotor Activity Of Mice. The 17th Joint Annual Conference of Biomesical Sciences P398.

2.   C.F. Huang, C.J. Hsu and S.Y. Lin-Shiau (2002). Effects of Mercury Sulfide on Auditory Brainstem Responses and Locomotor Activity of Mice. Neuroscience Society R.O.C. (Taiwan), p34.

3.   C.F. Huang and S.Y. Lin-Shiau (2003). The Death Signaling Pathway of Mercury Sulfide on The Culture Human Umbilical Vein Endothelial Cells. The 18th Joint Annual Conference of Biomesical Sciences ,P464.

4.   C.F. Huang, S.H. Liu, and S.Y. Lin-Shiau (2003). Studies on The Deaths Signaling in The Murine Macrophages Induced by HgS-Meatl Chelator Complexes. 2屆海峽兩岸毒理學研討會台北,台灣,2003.

5.   C.F. Huang, C.J. Hsu, and S.Y. Lin-Shiau (2003). Studies On The Altered Behaviors And Ototoxicity Found In The Third Generations Of The Cinnabar-Fed Mice. Neuroscience Society R.O.C. (Taiwan).

6.   S.Y. Lin-Shiau, C.F. Huang and S.H. Liu (2004). Implication of nitric oxide production in the altered behaviors of mice administered with combined lipopolysaccharide and methamphetamine. 3th Asian Society of Toxicology (ASIATOX)( Thailand).

7.   C.C. Yen, Y.W. Chen, C.F. Huang, S.H. Liu, S.Y. Lin-Shiau and W.K. Chen and F.J. Lu (2005). Cytotoxicity Of Mercurial Compounds In V79 And HL-60 Cells: Roles Of Glutathione And Oxidative Stress. The 20th Joint Annual Conference of Biomesical Sciences ,P653.

8.   C.C. Yen, Y.W. Chen, C.F. Huang, S.H. Liu, W.H. Chang, W.K. Chen and F.J. Lu (2005). Toxic Effects Of Humic Acid And Arsenic: The Relations With The Pathogenesis of Diabetes Mellitus. The 20th Joint Annual Conference of Biomesical Sciences ,P669.

9.   S.Y. Lin-Shiau, C.F. Huang, and S.H. Liu (2005). Modulatory effects of mercuric sulfide on behavioral changes of mice induced by methamphetamine. 物質濫用研討會,成功大學醫學院,台南,台灣,2005.

10. C.C. Yen, Y.W. Chen, C.F. Huang, S.H. Liu, W.H. Chang, W.K. Chen and F.J. Lu (2006). Humic Acid and Arsenic Reduce Insulin Secretion: The Relations with the Pathogenesis of Diabetes Mellitus In Vivo and In Vitro Experimentation. The 21th Joint Annual Conference of Biomesical Sciences ,P190.

11. Y.W. Chen, C.F. Huang, C.Y. Yang, Y.L. Leu, and S.H. Liu (2007). Extract From Angelica Hirsutiflora With Hypoglycemic Activity. The 22th Joint Annual Conference of Biomesical Sciences, P038.

12. Y.C. Tsai, C.F. Huang, Y.W. Chen, C.Y. Yang, J.R. Tsai, and S.H. Liu (2007). Studies on The Mechanism Of Action Of Oxidative Stress On The Regulation Of Insulin Secretion. The 22th Joint Annual Conference of Biomesical Sciences, P263.

13. C.Y. Yang, C.F. Huang, Y.W. Chen, C.C. Yen, S.H. Liu (2008). Mercury-Induced Pancreatic –Cell Death: Involvement of Apoptosis and Necrosis. Eighth Annual Rachmiel Levine Diabetes and Obesity Symposium (U.S.A.), P85.

14. C.F. Huang, Y.W. Chen, C.M. Hung, C.C. Yen, and S.H. Liu (2008). Extract Isolated From Semen Benincasae With Insulin Secretagogue Activity. The 23th Joint Annual Conference of Biomesical Sciences, P196.

15.  J.R. Tsai, C.F. Huang, Y.W. Chen, C.Y. Yang, and S.H. Liu (2008). Effects Of Tributyltin On The Pancreatic -Cell Growth And Function. The 23th Joint Annual Conference of Biomesical Sciences, P811.

 

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